IMPACTS OF STAPHYLOCOCCUS AUREUS RESISTANCE TO METHICILLIN IN NEONATAL INTENSIVE CARE UNITS

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Aline Caroliny Xavier da Silva
Telvania Alves Rodrigues Mesquita
Thiara Lorenna Bezerra da Silva Oliveira

Abstract

Bacterial resistance represents one of the greatest public health challenges, especially in Neonatal Intensive Care Units (NICUs). Methicillin-resistant Staphylococcus aureus (MRSA) is one of the main pathogens that cause neonatal nosocomial infections, significantly compromising the prognosis of vulnerable patients. This study aims to analyze the impacts of bacterial resistance of S. aureus to methicillin in NICUs, identifying risk factors, clinical manifestations, and prevention strategies. This is a literature review integrative carried out in the PubMed, BVS, LILACS, SciELO and Google Scholar databases, including articles published between 2020-2025 in Portuguese, English and Spanish. The selection followed pre-established criteria, and the analysis was conducted through narrative synthesis. A total of 21 studies were selected after applying the inclusion and exclusion criteria. The prevalence of MRSA in NICUs ranged from 2.1% to 37%, with a national average of 15.3%. Key risk factors include previous use of antimicrobials, invasive devices, and prematurity. Attributable mortality was 18.7% and additional costs vary between R$ 15,000 and R$ 42,000 per episode. It is concluded that MRSA represents a significant public health problem in NICUs, requiring the implementation of rigorous and multimodal control and prevention measures to reduce its impacts on neonatal health and hospital costs. 

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Author Biographies

Aline Caroliny Xavier da Silva, UNI-CET

Undergraduate student in the pharmacy program.

Telvania Alves Rodrigues Mesquita, UNI-CET

Undergraduate student in the pharmacy program.

Thiara Lorenna Bezerra da Silva Oliveira, UNI-CET

Bacterial resistance represents one of the greatest public health challenges, especially in Neonatal Intensive Care Units (NICUs). Methicillin-resistant Staphylococcus aureus (MRSA) is one of the main pathogens that cause neonatal nosocomial infections, significantly compromising the prognosis of vulnerable patients. This study aims to analyze the impacts of bacterial resistance of S. aureus to methicillin in NICUs, identifying risk factors, clinical manifestations, and prevention strategies. This is a literature review integrative carried out in the PubMed, BVS, LILACS, SciELO and Google Scholar databases, including articles published between 2020-2025 in Portuguese, English and Spanish. The selection followed pre-established criteria, and the analysis was conducted through narrative synthesis. A total of 21 studies were selected after applying the inclusion and exclusion criteria. The prevalence of MRSA in NICUs ranged from 2.1% to 37%, with a national average of 15.3%. Key risk factors include previous use of antimicrobials, invasive devices, and prematurity. Attributable mortality was 18.7% and additional costs vary between R$ 15,000 and R$ 42,000 per episode. It is concluded that MRSA represents a significant public health problem in NICUs, requiring the implementation of rigorous and multimodal control and prevention measures to reduce its impacts on neonatal health and hospital costs.