THE USE OF TIRZEPATIDE IN THE TREATMENT OF OBESITY AND ITS SIDE EFFECTS: AN INTEGRATIVE REVIEW
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Abstract
The rise in obesity has led to the emergence of chronic diseases, such as diabetes. Consequently, the
discovery of new hypoglycemic drugs, such as GLP-1 analogs, with liraglutide, semaglutide, and
tirrizepatide as prime examples, has focused on weight management and obesity control. The objective
of this study was to report the scientific evidence on the side effects related to the use of tirrizepatide in
the treatment of obesity, as well as to describe the therapeutic effects of the drug. This study is an
integrative literature review in which a search was conducted in the SciELO and LILACS databases (via
BVS). The studies analyzed revealed a growing panorama of obesity in Brazil and worldwide, as it
constitutes one of the greatest public health challenges, characterized as a multifactorial condition
involving biological, behavioral, and social determinants. In this sense, advances in pharmacological
therapies have become an ally in the management of obesity, with particular emphasis on the emergence
of Tizerpatide, which has demonstrated positive and significant results in appetite regulation, glycemic
control, improved metabolism, and reduction of body weight. Furthermore, most studies pointed to the
need for more research with long-term follow-up to evaluate the chronic effects of the medication.
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